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Polypharmacology : Strategies for Multi-Target Drug Discovery
Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examples Polypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer.The book provides practical guidelines and advice to help readers design drugs that have multiple targets while minimizing unwanted off-target effects, discusses important disease areas like viral infection, diabetes, and obesity that have advanced significantly in the last decade, and guides researchers in neighboring areas to polypharmacology.The book is divided into four parts. Part A covers the link between off-targets and adverse drug reactions, how to screen for off-target activity, and how to recognize and optimize compounds with a potential for off-target activity.Part B discusses disease areas which benefit from polypharmacological approaches.Part C highlights important approaches, such as compound design, data mining with web-based tools, and multi-target peptides.Part D provides case study coverage on topics like CDK4/6 inhibitors for cancer treatment, the potential of multi-target ligands for COVID, and protein degraders and PROTACs.Sample topics discussed in Polypharmacology include: Molecular properties and structural motifs in pharmacological promiscuity, covering lipophilicity, molecular weight, and other parametersKinase liabilities in early drug discovery, covering core kinases driving the cell division cycle and consequences of interference, and cell cycle checkpoints controlling cell divisionTreatment of major depressive disorder, covering tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin and norepinephrine reuptake inhibitorsTrends in the field, such as novel antipsychotics, standardization of screening tools, and the SmartCube System®, as well as lessons from history Delivering the latest research developments in the field, Polypharmacology is an essential reference on the subject for medicinal chemists, pharmacologists, biochemists, computational chemists, and biologists, as well as pharmaceutical professionals involved in drug discovery programs.
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Discovery of Grounded Theory : Strategies for Qualitative Research
Most writing on sociological method has been concerned with how accurate facts can be obtained and how theory can thereby be more rigorously tested.In The Discovery of Grounded Theory, Barney Glaser and Anselm Strauss address the equally Important enterprise of how the discovery of theory from data—systematically obtained and analyzed in social research—can be furthered.The discovery of theory from data—grounded theory—is a major task confronting sociology, for such a theory fits empirical situations, and is understandable to sociologists and laymen alike.Most important, it provides relevant predictions, explanations, interpretations, and applications.In Part I of the book, "Generation Theory by Comparative Analysis," the authors present a strategy whereby sociologists can facilitate the discovery of grounded theory, both substantive and formal.This strategy involves the systematic choice and study of several comparison groups.In Part II, The Flexible Use of Data," the generation of theory from qualitative, especially documentary, and quantitative data Is considered.In Part III, "Implications of Grounded Theory," Glaser and Strauss examine the credibility of grounded theory.The Discovery of Grounded Theory is directed toward improving social scientists' capacity for generating theory that will be relevant to their research.While aimed primarily at sociologists, it will be useful to anyone Interested In studying social phenomena—political, educational, economic, industrial— especially If their studies are based on qualitative data.
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Discovery
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Cuban Discovery
An island lost in time, Cuba is a decadent blend of romantic grandeur and off-beat Caribbean charm. Iconic 1950s automobiles parade through the seafront streets and rumba bars rub shoulders with centuries-old churches. Forested inland landscapes are home to tobacco plantations and rugged mountaintops, while swathes of white sand skirt the northern coast. On our tours of Cuba, we'll start in Havana before winding our way through the country, uncovering its treasures as we go - from Spanish colonial heritage to underground rivers.
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What tips are there for a discovery game on PC?
When playing a discovery game on PC, it's important to take your time and explore the environment thoroughly. Pay attention to any clues or hints provided in the game, as they may lead you to new discoveries. Utilize any tools or abilities at your disposal to uncover hidden secrets or areas. Additionally, don't be afraid to experiment and try different approaches to solving puzzles or uncovering new content. Finally, immerse yourself in the game's world and story to fully appreciate the experience of discovery.
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What is an old discovery?
An old discovery refers to a scientific or historical finding that was made a significant amount of time ago. These discoveries have often stood the test of time and have had a lasting impact on our understanding of the world. Examples of old discoveries include the theory of evolution by Charles Darwin, the discovery of electricity by Benjamin Franklin, and the invention of the printing press by Johannes Gutenberg. These discoveries have shaped our modern world and continue to be studied and celebrated for their significance.
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What was Luther's great discovery?
Luther's great discovery was the concept of justification by faith alone. He believed that individuals could be saved by their faith in God alone, rather than through good works or the sacraments of the Catholic Church. This idea challenged the traditional teachings of the Church and sparked the Protestant Reformation. Luther's emphasis on faith as the key to salvation had a profound impact on Christianity and led to the formation of new Protestant denominations.
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Series like Star Trek: Discovery
Series like Star Trek: Discovery are typically science fiction shows that explore themes of space exploration, advanced technology, and diverse alien cultures. They often feature a diverse cast of characters and focus on moral and ethical dilemmas faced by the crew. These series also tend to have high production values, intricate storylines, and a mix of action and drama. Fans of Star Trek: Discovery may enjoy other similar shows like The Expanse, Battlestar Galactica, and Doctor Who.
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Above Discovery
A collection that careens from Ancient Greece to the Klondike Gold Rush, for readers of A.S. Byatt and Margaret Atwood. “It is the part that is missing that I am drawn to, that I try to pin down.My gaze is always divided by what is here and what is no longer here.That, for me, is where the deepest pleasure lies, where the sweet overcomes the bitter."A couple coping with a recent loss are tasked with taking stock of a late biology enthusiast’s hoard.A support worker dedicated to rehabilitating young women suffering from, among other things, a certain unexpected effect of the climate apocalypse faces a truth that shatters the illusion separating her work and her personal life.An archaeologist formerly working in Syria struggles with her decision to flee from unrest, while the people she has left behind face an uncertain fate. In Jennifer Falkner’s richly imagined first collection, past and present glancingly converge, making the familiar outlines of myth, history, and everyday life seem suddenly strange.With spare, elegant prose, Falkner introduces the reader to those whose narratives are written in the language of empty space.Above Discovery is a stunning debut collection from an author to watch.
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Vietnamese Discovery
Travelling from high-energy cities to sleepy backwaters, ancient citadels to karst-dotted bays, our small-group Vietnam tours showcase everything that we love about this country. You’ll explore Hanoi’s labyrinthine Old Quarter and Ho Chi Minh City’s Parisian-style boulevards. You’ll help out on a rural farm and enjoy lunch with locals. You’ll sip salt coffee and sample rice paper snacks. And you’ll sail the serene waters of Halong Bay and Lan Ha Bay on an unforgettable 2-night cruise. Welcome to Vietnam…
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Discovery
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Discovery
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What is your latest discovery?
My latest discovery is a new method for synthesizing a novel class of organic compounds with potential applications in drug development. By using a combination of computational modeling and organic synthesis techniques, my team and I were able to design and create these compounds with improved properties compared to existing ones. This discovery has the potential to open up new avenues for the development of more effective and targeted medications for various diseases.
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What was the gold discovery?
The gold discovery refers to the event in 1848 when gold was discovered at Sutter's Mill in California, sparking the California Gold Rush. The discovery led to a massive influx of people from all over the world seeking their fortunes in gold mining. This event had a significant impact on the development of California and the United States, as it led to rapid population growth and economic prosperity in the region.
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What kind of discovery is this?
This discovery is a significant scientific breakthrough in the field of astronomy. The detection of a new exoplanet, especially one that is potentially habitable, is a rare and exciting find. It opens up new possibilities for studying the potential for life beyond our solar system and deepens our understanding of the universe.
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What is the discovery of radioactivity?
The discovery of radioactivity is the phenomenon where certain elements spontaneously emit radiation in the form of particles or electromagnetic waves. This was first observed by Henri Becquerel in 1896 when he noticed that uranium salts emitted rays that could expose photographic plates. This discovery led to further research by Marie and Pierre Curie, who identified the elements polonium and radium as being radioactive. Radioactivity has since been found to have important applications in medicine, industry, and energy production.
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